STATUS MENOPAUSE DAPAT MENINGKATKAN KADAR ASAM URAT
DOI:
https://doi.org/10.55129/jnerscommunity.v10i2.867Abstrak
Hiperurisemia menjadi salah satu kondisi tidak sehat yang kurang disadari di Indonesia. Kondisi ini memiliki keterkaitan dengan status kesehatan seseorang dan faktor resiko lain yang tidak dapat dimodifikasi seperti pengaruh hormonal, salah satunya adalah hormon estrogen. Penelitian ini bertujuan untuk mengetahui hubungan status menopause dengan kadar asam urat.
Penelitian ini menggunakan pendekatan cross-sectional dengan 105 responden yang telah diambil melalui purposive sampling berdasarkan kriteria inklusi dan eksklusi. Variabel X adalah status menopause. Variabel Y adalah kadar asam urat. Data status menopause diklasifikasikan sesuai katgeori NOWAC menjadi premenopause dan postmenopause. Pengukuran kadar asam urat menggunakan GCU meter. Indeks massa tubuh (IMT), jenis kelamin dan usia digunakan sebagai data tambahan. Tinggi dan berat badan diukur untuk menghitung nilai IMT, kemudian diklasifikasikan sesuai dengan kategori IMT menurut Kemenkes RI. Data terkait jenis kelamin dan usia cdiambil sesuai dengan keterangan di kartu identitas (KTP). Software statistik digunakan untuk analisis data, hubungan antara status menopause dengan kadar asam urat diuji menggunakan Chi-square dengan tingkat signifikansi?0,05.
Terdapat hubungan yang signifikan antara status menopause dengan kadar asam urat p=0,000, OR=4,750 pada perempuan postmenopause dibanding premenopause, OR=1,425 laki-laki dibanding postmenopause dan OR=6,769 pada laki-laki premenopause.
Laki-laki dan perempuan post menopause memilki resiko hiperurisemia yang lebih tinggi, sehingga mereka seharusnya lebih berhati-hati terhadap faktor resiko yang lain sedangkan perempuan premenopause harus mempertahankan IMT yang ideal untuk kadar asam urat yang normal.
Kata Kunci: Asam urat, Estrogen, IMT, Menopause
DOI: 10.5281/zenodo.3561962
Referensi
Barbieri, L. et al. (2014) ‘Impact of sex on uric acid levels and its relationship with the extent of coronary artery disease: A single-centre study’, Atherosclerosis. Elsevier Ltd, 241(1), pp. 241–248. doi: 10.1016/j.atherosclerosis.2015.03.030.
Chaudhary, K. et al. (2013) ‘Uric acid-key ingredient in the recipe for cardiorenal metabolic syndrome’, CardioRenal Medicine, 3(3), pp. 208–220. doi: 10.1159/000355405.
Das, M. et al. (2014) ‘Reference Ranges for Serum Uric Acid among Healthy Assamese People’, 2014.
Doshi, S. B. and Agarwal, A. (2013) ‘The role of oxidative stress in menopause’, 4(3). doi: 10.4103/0976-7800.118990.
Fang, J. I. et al. (2014) ‘High uric acid level associated with increased arterial stiffness in apparently healthy women’, Atherosclerosis. Elsevier Ltd, 236(2), pp. 389–393. doi: 10.1016/j.atherosclerosis.2014.07.024.
Guan, S. et al. (2016) ‘Prevalence of hyperuricemia among Beijing post-menopausal women in 10 years’, Archives of Gerontology and Geriatrics. Elsevier Ireland Ltd, 64, pp. 162–166. doi: 10.1016/j.archger.2016.02.002.
Hastuti, V.N, et al. (2018) ‘Hubungan asupan protein total dan protein nabati terhadap kadar asam urat dalam darah pada wanita menopause’, Journal of Nutrition, 7. doi: htttps://doi.org/10.14710/jnc.v7i2.20823.
Joo, J. K. et al. (2014) ‘The Association between Serum Uric Acid Level and Incidence of Metabolic Syndrome according to Menopausal Status in Korean Women’, Journal of Menopausal Medicine, 20(3), p. 126. doi: 10.6118/jmm.2014.20.3.126.
Kemenkes (2019) Hasil Riskesdas 2018. Available at: http://www.depkes.go.id/resources/download/info-terkini/hasil-riskesdas-2018.pdf.
Liu, J. et al. (2018) ‘Gender differences in the association between serum uric acid and prediabetes: A six-year longitudinal cohort study’, International Journal of Environmental Research and Public Health, 15(7). doi: 10.3390/ijerph15071560.
M.K. Hatayama (2015) ‘Nonpharmalogical Management of Gout and Hyperuricemia: Hint for Better Lifestyle’, American Journal of Lifestyle Medicine, Sage Pub 2, p. 10. doi: 10.1177.1559827615601973.
Maiuolo, J. et al. (2016) ‘Regulation of uric acid metabolism and excretion’, International Journal of Cardiology. Elsevier B.V., 213(August), pp. 8–14. doi: 10.1016/j.ijcard.2015.08.109.
Mandal, A. K. and Mount, D. B. (2014) ‘The Molecular Physiology of Uric Acid Homeostasis’, Annual Review of Physiology, 77(1), pp. 323–345. doi: 10.1146/annurev-physiol-021113-170343.
Mumford, S. L. et al. (2013) ‘Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study.’, Human reproduction (Oxford, England), 28(7), pp. 1853–1862. doi: 10.1093/humrep/det085.
N. Ishizka (2010) ‘Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals’, Journal Rheumatol, 37, pp. 410–416.
Niwa, K. et al. (2018) ‘Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan’, International Journal of Cardiology. Elsevier B.V., 261, pp. 183–188. doi: 10.1016/j.ijcard.2018.03.045.
Nuttall, F. Q. (2015) ‘Body Mass Index’, Nutrition Today, 50(3), pp. 117–128. doi: 10.1097/NT.0000000000000092.
Preedy, V. R. (ed.) (2012) Handbook of Anthropometry. Springer US. doi: 10.1007/978-1-4419-1788-1.
Rashad, N. M. and Ibrahim, T. M. H. (2017) ‘Association of hyperuricemia with Obesity and Metabolic Co-Morbidities among Post-Menopausal Egyptian Women’, (May). doi: 10.21275/ART20172735.
Sekhon, L. H. and Agarwal, A. (2013) ‘The Menopause and Oxidative Stress’, pp. 181–203. doi: 10.1007/978-1-62703-041-0.
Song, G. G. et al. (2017) ‘Serum uric acid levels and hormone therapy type’, Menopause, 25(1), pp. 77–81. doi: 10.1097/gme.0000000000000953.
Tamura, M. et al. (2013) ‘Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity’, Journal of Biological Chemistry, 288(38), pp. 27138–27149. doi: 10.1074/jbc.m113.485094.
Tanaka, H. et al. (2015) ‘The relationship between body mass index and uric acid: a study on Japanese adult twins’, Environmental Health and Preventive Medicine. Springer Japan, 20(5), pp. 347–353. doi: 10.1007/s12199-015-0473-3.
Villegas, R. et al. (2012) ‘Purine-rich foods , protein intake , and the prevalence of hyperuricemia : The Shanghai Men ’ s Health Study’. doi: 10.1016/j.numecd.2010.07.012.
Waaseth, M. et al. (2008) ‘Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort - A cross-sectional analysis’, BMC Women’s Health, 8(May 2014). doi: 10.1186/1472-6874-8-1.
Wang, H. et al. (2014) ‘Association of Serum Uric Acid with Body Mass Index: A Cross-Sectional Study from Jiangsu Province, China.’, Iranian journal of public health, 43(11), pp. 1503–9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26060717%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4449499.
World Health Organization (2000) Sexual and Reproductive Health. Available at: https://www.who.int/reproductivehealth/topics/sexual_health/sh_definitions/en/ (Accessed: 30 March 2019).
Xu, Y.-L. et al. (2016) ‘Elevation of serum uric acid and incidence of type 2 diabetes: A systematic review and meta-analysis’, Chronic Diseases and Translational Medicine, 2(2), pp. 81–91. doi: 10.1016/j.cdtm.2016.09.003.
Yadav, B. K. et al. (2009) ‘Serum Uric Acid Level in Obese and Non-obese Individuals’, Jnamls, 10(1), pp. 27–30.
Yracheta, J. et al. (2018) ‘Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects’, Nutrients, 10(8), p. 1011. doi: 10.3390/nu10081011.
Zhang, X. et al. (2018) ‘The prevalence of hyperuricemia and its correlates in Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China’, Lipids in Health and Disease. Lipids in Health and Disease, 17(1), pp. 1–10. doi: 10.1186/s12944-018-0882-6.
Zhang, Y. et al. (2014) ‘Association of Uric Acid with Metabolic Syndrome in Men, Premenopausal Women and Postmenopausal Women’, International Journal of Environmental Research and Public Health, 11(3), pp. 2899–2910. doi: 10.3390/ijerph110302899.

